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Silymarin is generally very well tolerated, with a low incidence of adverse events and no treatment-related serious adverse events or deaths reported in clinical trials

The short TM4 sequence C P C is characteristic of both P 1B-1 and P 1B-2 transporters, widely accepted to transport Cu I and Zn II /Cd II /Pb II , respectively, but each differs on the basis of residues in TM6 (Figure 56)

Most common adverse events at all doses: Nausea (15-30%, dose-related) Vomiting (5-15%) Decreased appetite (~20%) Constipation (5-12%) Cagrilintide-specific notes: A 2025 Bayesian network meta-analysis of incretin-based therapies reported cagrilintide had one of the lowest GI odds ratios across the studied compound class