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Nanotechnological strategies to improve the delivery of therapeutic compounds to the brain have undergone significant advances, which is particularly relevant for optimizing HTX bioavailability [87]

Consistently, in a CRPS model, the spinal cord showed increased populations of reactive astrocytes and microglia were observed in the spinal cord, along with elevated expression of the M1 marker CD86 and reduced Arg-1 expression, indicating a preferential M1 microglial polarization in NPP (122)

Additionally, dynamic monitoring of drug resistance, such as through liquid biopsy, along with the use of combination therapies (e.g., PD-1 inhibitors and PARP inhibitors), offers further potential for improving therapeutic outcomes

Chronic inflammation can arise from excessive or continued stimulation of immune cells from ongoing infection and/or incomplete removal of stimulants (e.g., particulate matter, oxidized materials) 9 , with this resulting in ongoing damage to tissues, with subsequent poor repair and remodelling (reviewed) 8