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Environmental factors associated with neurodegeneration are diet, lifestyle, and chemical exposures such as metals mercury, cadmium, inorganic arsenic, and pesticides (e.g., deltamethrin, paraquat, dieldrin and rotenone) [3, 7], whereas environmental factors that have been shown to reduce the incidence of neurodegeneration are nicotine, caffeine, statins, post-menopausal hormonal treatment and non-steroidal anti-inflammatory drugs such as ibuprofen [3, 8]

Risk of dementia in APOE 4 carriers is mitigated by a polygenic risk score