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Therefore, low cellular energy states will lead to induction of 2-oxoglutarate production via the glutamate dehydrogenase reaction allowing for increased ATP synthesis from the TCA cycle-derived NADH and FADH 2

CTE is characterized by the accumulation of abnormal tau protein in specific brain regions

To further investigate the role of lipid catabolism in fasting-induced longevity, we examined two key regulators: Adipose Triglyceride Lipase-1 (ATGL-1), which initiates lipolysis, and Carnitine Palmitoyl Transferase-2 (CPT-2), which catalyzes carnitine removal and Coenzyme A conjugation to the fatty acid within the mitochondrial matrix 43,44