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In the body: Glutamic acid becomes glutamate at physiological pH
The peptides ability to produce metabolic effects with such rapid plasma clearance (3-minute half-life) while maintaining prolonged biological activity represents a significant knowledge gap requiring further investigation
58(Suppl 1): 37-52
Upon stimulation, IL-6 is secreted by many additional cell types including macrophages, T cells, B cells, mast cells, glial cells, eosinophils, keratinocytes, and granulocytes
