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Glyoxalases, the key enzymes in the detoxification of methylglyoxal, a byproduct of glycolysis and precursor of advanced glycation end-products, are compromised by oxidation and downregulation

Moreover, some other animal studies have reported a similar effect of riboflavin on SOD ( Reference Liang, Liu and Xu 23 , Reference Hirano, Hamajima and Horiuchi 34 , Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 ) , GPx ( Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 , Reference Wang, Mei and Chen 36 ) and catalase ( Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 , Reference Lee, Ye and Jones 37 ) activities

(PubMed) A third mechanism is oxidative stress reduction

While our bodies produce their own supply, various factors can deplete our stores