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In order for ascorbate to be able to reach tissues, it must go through the endothelial barrier of each tissue

The failure of this clearance pathwaydue to loss of TREM2 hi macrophages, receptor deficiency, or an overwhelming burden of debrishas dire consequences

The morphological features of ferroptosis primarily involve mitochondrial alterations including rupture of the mitochondrial membrane, reduced mitochondrial size with increased mitochondrial membrane densities, and loss of mitochondrial cristae (Li J

K., Jain, J., Yadav, R
