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However, the majority of them may still induce certain undesirable effects, including stomatitis, hyperlipidemia, rash, myelosuppression, and hyperglycemia [125]
doi: 10.1007/s10989-016-9551-7 121 XieYZhangYZhangLTZengSXGuoZBZhengBD

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The risk of recurrence with every operation is greater than the risk for the previous operation