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Research has shown arrhythmia prevention in models of both hyperkalemia (too much potassium) and hypokalemia (too little potassium), conditions that commonly trigger dangerous heart rhythm disturbances

The vaccine fact sheet says this: Immunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to the Pfizer-BioNTech COVID-19 Vaccine
Laboratory estradiol levels in postmenopausal people are usually less than 20 pg/mL (73 pmol/L) (25)

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