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As with any cosmetic procedure, technique is extremely important to achieve the desired effect with natural appearance
As a consequence, human cells with additional chromosomes suffer from proteotoxic stress, as documented by increased sensitivity to chaperone inhibitors, accumulation of ubiquitin- and p62-positive cytosolic bodies and increased lysosomal stress 8,9,14,15,16,18
In agreement with these preclinical studies, postmenopausal women are at increased risk of obesity, insulin resistance, osteoporosis, cardiovascular disease, and cognitive decline [90]
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