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In their case they calculated the average number of mutations per culture 'from the proportion of cultures containing no resistant bacteria at the moment of the test' in accordance with Poisson's law (Luria, Delbrck)

For oral dosing, yes taking it with food reduces absorption

However, this central assumption has been shown to be a major oversimplification (318)

Rhinovirus is associated with the development of allergic asthma in children, and RSV is associated with non-allergic asthma.[ref] One study found that wheezing was associated with viral detection in 100% of children and 80% of adults with asthma exacerbation