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Description
Subsequently, the aspartateglutamate antiporter (encoded by SLC25A13 gene) exports aspartate into the cytosol where cytosolic glutamic-oxaloacetic transaminase (GOT1) transfers an amino group from aspartate to ketoglutarate to produce glutamate and oxaloacetate to complete the cycle, which is, in turn, reduced to malate in conjunction with oxidizing NADH to NAD + by cytosolic MDH (Fig
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Mitochondria serve as a major ROS generator and, at the same time, as a ROS receptor
Cancer Drug Targets 11 (3), 325331
