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This bindings dynamic nature is intriguing

doi: 10.1016/j.apjtm.2016.01.023

[DOI] [PubMed] [Google Scholar] 333.Heppner K.M., Piechowski C.L., Muller A., Ottaway N., Sisley S., Smiley D.L

Upon stress, Sestrin2 activates AMPK, which promotes the phosphorylation of tuberous sclerosis complex 2, leading to mTORC1 inhibition (Wolfson et al., 2016)
