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When solutes are added to partitioning systems (multiphasic systems), they distribute according to their solubility in the various phases, a phenomenon widely employed in a plethora of applications, including basic science and relevant economic areas such as medicine, pharmacy and food technology

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These findings emphasize the need of swift freezing or analysis of the metabolites, with a maximal time of four hours of exposure to room temperature to prevent significant metabolite dynamics in vitro

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