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3.2 Macrophages In a hypoxic environment, the activation of HIF-1 specifically promotes glycolysis in monocytes and macrophages, thereby enhancing their antigen presentation capabilities and secretion of inflammatory factors (69)
SAAR shifts the fate of glucose towards liver asparagine In addition to de novo serine synthesis, this study demonstrates that SAAR stimulates glucose partitioning towards asparagine synthesis
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For example, metformin is well-known for its diverse effects, including recently reported anti-inflammatory activity
