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More research is needed to unravel the intricacies of its mechanisms and explore its therapeutic potential in the prevention of apoptosis-related conditions, especially in the male reproductive system

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Immune Reconstitution Syndrome Advise patients to inform their healthcare provider immediately of any symptoms of infection, as in some patients with advanced HIV infection (AIDS), signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started [see Warnings and Precautions (5.3)]

Similar alterations have been reproduced in animal models exposed to testosterone esters or nandrolone decanoate, in which mitochondrial dysfunction and caspase-mediated apoptosis occur within Leydig and Sertoli cells (79)