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Common Surgeries Associated with Post-Surgical Melena Some surgeries are more likely to cause melena because they affect the upper GI tract

This was followed by active clinical development for the treatment of several autoimmune diseases, and the first indication for which efgartigimod entered late-stage clinical trials was gMG, which was found to be ameliorated by intravenous (i.v.) delivery of efgartigimod in a pivotal, proof-of-concept, phase II study in 2019 [227]

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This may be due to the insufficient sample size in preclinical studies, physiological and pathological differences between humans and experimental animals, and methodological shortcomings that were either not reported or not tracked over the long term in earlier studies