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Recommendations 13 Lipid profile flags should be based on thresholds related to increased ASCVD risk

Outperforms LDL-C in Modern Meta-Analyses A major analysis published in 2025 looked at results from multiple clinical trials involving different cholesterol-lowering treatmentssuch as statins, ezetimibe, and PCSK9 inhibitors

This inconsistency is likely attributable to critical experimental variables such as species differences, dosage, exposure duration, and overall study design 73