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Description
Escalation of pro-inflammatory mechanisms shifts the CS paradigm toward cell-cycle blockade
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With the help of such systems, the highest plasma concentrations, a stable release profile, and significantly increased relative bioavailability have been achieved [73,74,75,76]
Additionally, hyperinsulinemia induces a pro-contractile phenotype in airway smooth muscle (ASM) cells and increases their sensitivity to neural-mediated bronchoconstriction [48,49,50]
