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These studies typically enroll a small cohort of 20 to 100 healthy volunteers, though patients with the target disease may be used for highly toxic medications like chemotherapeutics

Abcam, Cambridge, United Kingdom), monoclonal anti-mouse SMA (1:1000, ab7817

PXR increases CYP3A4, an important phase I oxidative enzyme that is responsible for the metabolism of many drugs

Vascular Endothelial Growth Factor (VEGF) as a Target of Bevacizumab in Cancer: From the Biology to the Clinic
