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A balanced -6/-3 ratio is indeed important to support the anti-inflammatory profile of -3 PUFA, and a varied diet should include balanced amounts of each PUFA class with a predominance of -3

doi: 10.1210/jcem-42-1-197

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Additionally, the combination of both enzymes converts -carotene to canthaxanthin and lutein to -doradexanthin, indicating that the primary reaction involves oxygenation of the C4 positions of the -endogroups with minimal hydroxylation reaction