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Conversely, if FeS cluster formation requires complex polypeptides or even genetically encoded proteins then other processes would be needed to bridge the biosynthetic gap to a polymer world

Nordstrom AL, Farde L, Wiesel FA, Forslund K, Pauli S, Halldin C et al

This article further reviews the latest progress in iron-targeting drug development, encompassing natural compounds (e.g., Diosgenin, Nuciferine, Xanthohumol), artificial extracts (e.g., sulfated polysaccharides), small molecule inhibitors (e.g., GLX351322), modifications of traditional drugs (e.g., Donafenib), and novel nanomaterials (e.g., GOA/miR-targeted nanocomposites, mitochondrial-targeted antioxidants like MitoTEMPO and MnO2Nfs), while also examining the potential limitations of these strategies