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In the context of the pathophysiology of AD, due to the fact that, at the present stage, there are no results linking additional epigenetic mechanisms with the pathogenesis of the disease, only the main mechanisms are considered here: chromatin remodeling, DNA methylation, and ncRNA [103]

Though several publications (Dourson et al., 2017

This complete absence of tolerability-driven discontinuations represents a remarkable safety finding and indicates that even when mild side effects occurred, they were sufficiently manageable that participants chose to continue treatment