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10.1136/bmjopen-2019-033687 46 SharabiA.CohenE.SulkesJ.GartyM

Further, the fact that the patients to be enrolled will be seeking medical help (although not necessarily for vitamin B12 deficiency) suggests few will be lost to follow-up

these hormones can exert specific physiological effects at very low concentrations [27]

Yes if they are not undergoing active treatment and if there is a clear indication such as post-surgical recovery, radiotherapy-related tissue repair, or immune support