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Studies have revealed that LCAC colocalizes with resident microglia/macrophages at the edge of spinal cord injury (SCI), indicating its potential involvement in the pathophysiology of SCI progression [114]

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The SCD aims to reduce gut inflammation and dysbiosis by eliminating fermentable carbohydrates that feed pathogenic bacteria and yeasts[127]

Indeed, VLCKD has shown to reduce inflammation through several mechanisms, i.e.by inhibiting activation of the nuclear factor kappa-light-chain-enhancer of activated B cells, and the inflammatory nucleotide-binding, leucine-rich-containing family, pyrin domain-containing-3, and inhibiting histone deacetylases [56]