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Carnitine in disease and therapy Since L-carnitine impacts the energy metabolism of almost every cell, carnitine depletion can manifest as age-related chronic and degenerative diseases

Prevention of bacterial TMAO formation through competitive inhibition of the bacterial carnitine palmitoyl transferase-1 (CPT-1) has also been observed to be possible with meldonium

The renal threshold for carnitine excretion is about 50 mol/L that is about the same value of the normal carnitine plasma concentration [18]

Furthermore, imatinib that is the first-line treatment of patients with chronic myeloid leukemia seems to be transported in cells by OCTN2 and OCTN1 (Hu et al., 2008 and Table 1)