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14,15 Each agent carries a black box warning stating that the drug may cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders

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Based on controlled clinical and epidemiological stopwatch studies, Waldinger and Schweitzer 22 proposed a new classification of PE in which four PE subtypes were distinguished on the basis of IELT duration, frequency of complaints, and course in life, which included variable PE and subjective PE in addition to lifelong PE and acquired PE