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Many - glucan receptors in macrophages and dendritic cells including Dectin-1 and TLRs are essential for recognizing - glucans, but the precise signaling pathways that lie downstream from each receptor are unknown

5 The etiology and pathogenesis of TS are comprehensive and unclear, potentially involving a combination of genetic factors, structural abnormalities in the central nervous system, neurotransmitter and immune imbalances, as well as psychological and environmental influences