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Keywords: heavy AOD use, alcoholic liver cirrhosis, alcoholic hepatitis, ethanol metabolism, biochemical mechanism, toxic drug effect, inflammation, drug therapy, hereditary factors, gender differences, diet, risk factors, endotoxin, fibrosis, free radicals, etiology, literature review An association between liver disease and heavy alcohol consumption was recognized more than 200 years ago (Smart and Mann 1992)

doi: 10.1203/01.PDR.0000161406.19231.98 29 BernsteinDLKameswaranVLe LayJESheafferKLKaestnerKH