g6pd reduced glutathione You Need More Riboflavin with Deficiency! – Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency

Based on basic MichaelisMenten enzyme kinetics, by supplying the extra substrate and cofactor (i.e., folate and riboflavin) the reduced affinity can be overcome and the consequences of having the variant can be alleviated, e.g., reduction in elevated homocysteine, reduction in blood pressure, etc. This is the very definition of personalized nutrition, in this case an increased requirement of two essential nutrients based on a common genetic difference

A summary of these recommendations is listed in Table 7

& Desai, A

Difficulty identifying the cause of hemolytic anemia should raise suspicion for glutathione synthetase deficiency (02)