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This multifaceted immunomodulation shifts the immune balance from pro-inflammatory to anti-inflammatory states, thereby reducing neuroinflammation and preserving neuronal integrity in PD pathogenesis

It is important to clarify that while cell-intrinsic genetic differences are also a crucial determinant of sexual dimorphism, this review will primarily focus on a detailed examination of sex hormones as a key endocrine regulatory layer

This score uniquely integrates cholangiographic findings which are crucial for distinguishing PSC from AIHwith a family or personal history of autoimmunity

The stress of living with a genetic condition like hemochromatosis can itself contribute to oxidative stress and inflammation