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Two to three-month-old of both sexes SCD mice were treated with 50 mg/kg DMF (#242926, Sigma) every other day for 4 weeks

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These alterations could impair the ability of the RBCs to transport oxygen and eventually trigger their removal from the blood circulation (Kuhn et al., 2017)

This notion is further supported by recent work suggesting that human primary motor and somatosensory cortices show proportionally steeper trajectories of volume, myelin, and iron declines with advancing age compared to other brain regions (Taubert et al., 2020)