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Description
Sometime after stress, typically 5-10 minutes, the hypothalamus-pituitary-interrenal axis will have activated interrenal cells to produce cortisol that will stimulate the restoration of energy supplies, and in the long term will help reduce energy costs by downregulating non-essential processes such as immune responses and growth

Front Neurol 13:1019554 Published 2022 Nov 9

It is often advisable to start with a lower dose (e.g., one capsule daily) and gradually titrate up to the full dose as tolerated
J., Freedland, K
