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However, the recovery of these regenerative capabilities (by increased expression of NAMPT for example) change the physiology of the cells towards stem-like cells, gaining some cancer properties, such as unlimited proliferative capacity, altered metabolism, DNA-repair, methylation alterations, with phenotype similar to CSCs, which deregulation by any other mutation initiate the tumor

doi: 10.1016/j.bbrc.2004.06.123 52 TilgHVannierEVachinoGDinarelloCAMierJW

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