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In the chronic IOP elevation model induced by microbead injection into the anterior chamber, the IOP-elevated mice fed with EGCG-supplemented drinking water showed a higher RGC density than those fed with normal drinking water at Day 15 and 27 post-injury [114]

These discrepancies may reflect differences in study design, treatment protocol, population genetics, or definitions of toxicity

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83 Further investigations identified late cornified envelope 1 (Lce1) family members as target genes of Nrf2 that function in compensatory mechanisms to counteract the loss of loricrin