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Pattern of hereditary hemochromatosis: pronounced parenchymal siderosis (accumulation of hemosiderin within the tissue) in hepatocytes and bile duct epithelium Pattern of secondary iron overload: Kupffer cells (specialized macrophages) containing hemosiderin Presence and degree of hepatic fibrosis (see Pathophysiology in Cirrhosis) The use of liver biopsy in hemochromatosis is limited, as the concentration and distribution pattern of hepatic iron can be assessed using noninvasive MRI

In MS, autoreactive leukocytes enter the CNS after peripheral activation of cellular migration molecules together with chemokine and adhesion receptors 23,102 (Fig

[DOI] [PubMed] [Google Scholar] 83.Jancova P., Anzenbacher P., Anzenbacherova E

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