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The study CheckMate-025 (NCT01668784) 40 is a randomized, open-label, phase 3 study that evaluates PFS and OS in two treatment arms, nivolumab versus everolimus, in patients with advanced or metastatic clear-cell RCC with measurable disease according to the RECIST criteria (v.1.1) and after at least one anti-angiogenic therapy

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This protocol provides an overview of chronic venous disease and its various manifestations, particularly varicose veins

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