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Description
Status of clinical trials involving anti-IGFs and IGF-1R mAbs The preclinical findings that support IGF-1 and its receptor IGF-1R as potential therapeutic targets led to the initiation of many clinical trials in the last decade (Table 1)
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Furthermore, targeting regulators within the crosstalk itself, such as knocking down deltex E3 ubiquitin ligase 2 to stabilize NCOA4 and promote ferritinophagy, can mitigate cisplatin resistance in NSCLC (121)
Castro, B
