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Theoretical concerns The limited human research on these peptides means some potential concerns remain theoretical: Cancer risk: Any peptide that promotes cell proliferation and blood vessel formation raises questions about potential effects on existing tumors

doi: 10.1080/10408398.2021.1903382 6 AtwoodDPaisley-JonesC

20 A gene ontology analysis indicated that SPPEPS upregulated chondrogenesis-related genes such as ENPP1 and CLIC4

Indeed, the odds of developing late AMD, especially neovascular AMD, was lower in both participants with a low risk of developing AMD and those who were at risk and recommended to continue taking the AREDS formulation after the trial ended