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LPS plus IFN- treatment remarkably increased the mRNA levels of Tnf- , Il-6 , Il-1 , iNos and Mcp-1 in BMDMs, whereas 100 M LC reversed the increased levels of the cytokines (Fig

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The flexible loop is expected to be stabilized in vivo by adopting a closed structure binding the substrate aldimine, whereas the apoenzyme does not bind the substrate, leading to its preferential proteolysis (Matsuda et al., 2004)

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