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This hydration effect can result in smoother, supple skin and can help alleviate dryness and roughness

Free radicals mediate the mitochondrial membrane depolarization and release of cytochrome C which in turn activate and induce the apoptosis process.114,115 A single study has reported the protective role of melatonin against vancomycin-induced nephrotoxicity in comparison with other important antioxidants.116 Intraperitoneal administration of vancomycin 10mg/kg, for 7 days, severely enhanced the serum creatinine, urea and malondialdehyde (MDA) levels which indicated the impaired renal function and cellular injury

Human studies need to be more robust to be able to comment on the safety of the long-term use of these peptides

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Palou A., Serra F., Pico C