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Curcumin has shown inhibition of 50% HDAC activity at a very high concentration of 500 M in HeLa nuclear extracts (with IC50 value of 115 M)
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Even though physician practice varies significantly, the practice guideline continues to provide a useful framework for evaluating infants and young children with fever ( Figures 3 1 and 4 1,10,13,14 )
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