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However, it is important to acknowledge that much of the current evidence supporting the efficacy of dietary interventions in AD is derived from preclinical models and observational cohort studies, both of which are inherently limited in their ability to establish causal relationships

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If incubation with compounds is prolonged, superior efficacies can be reached: after 72 h exposure of NTS to compounds 1 and 6 had LD 50 s of 2.2 0.19 and 7.8 2.36 M respectively, whereas 2 had 0.18 0.007 M

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