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Multi-week culture studies examining collagen, elastin, and proteoglycan gene expression often require repeat dosing of cultures across several passages, which draws down stock material more quickly than a single-endpoint assay

Zeng, Z
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Nature 355(6359):441446 Zheng J-N, Zhuo J-Y, Nie J, Liu Y-L, Chen B-Y, Wu A-Z, Li Y-C (2021) Phenylethanoid glycosides from Callicarpa kwangtungensis Chun attenuate TNF--induced cell damage by inhibiting NF-B pathway and enhancing Nrf2 pathway in A549 cells