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IYASHITA-ISHIWATA et al

So, sugar can cause us to miss the opportunity to nourish our health with foods that actually give us the nutrition that we need in order to thrive

In addition to these, the augmentation of the EPR effect can also be done by employing some classical methods like a pharmaceutical-based approach, which includes the administration of angiotensin-II, bradykinin, and TNF-, or a physical approach such as hyperthermia, radiotherapy has the potential to be exploited for the partial improvement in the EPR-mediated tumor targeting (Table 2) [67, 68, 110], but they are not enough to treat the cancer patients suffering from non-leaky tumors, and therefore they could not be benefitted from the EPR principle