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10.1016/s0304-3940(98)00711-3 Neurosci Lett

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While rats receiving the same dose, i.e., 15.6 /mcg/kg bodyweight of fentanyl (0.3MAC), for 6 consecutive days showed increase of transaminases, mainly GPT, also known as ALT, after repeated injections of fentanyl, with no evidence of liver necrosis ( Still, to make matters more complicated, all the anesthetics have long ago been hypothesized that could affect the liver through perturbing the permeability of liposome membranes and consequently impairing cell functions ( In eliciting hepatotoxicity, the role of the liver detoxification system is expected to be highlighted