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Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)

Influenced by pro-tumorigenic cytokines, cancer cells acquire stem cell properties that promote cancer aggressiveness and resistance to therapy

rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing

This can minimize the risk of adverse reactions and maximize the efficacy of the treatment