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Role of ammonia-induced increased GABAergic tone

Preclinical and mechanistic studies indicate that AZD3965 is particularly effective in tumors characterized by high MCT1 and low MCT4 expression, especially in certain lymphoma subtypes, where inhibition of lactate transport induces intracellular acidification and metabolic stress

We interpret the first phase as the glutathionylation of the PfGrx moiety that became detectable for the nearby fraction of fused roGFP2 molecules (Fig

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