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Sin embargo, este estudio tena limitaciones significativas, como la falta de un grupo de control y el pequeo tamao de la muestra
3.1.1 Regulation of ferroptosis The state and expression levels of critical regulatory proteins in the cell determine how the cell responds to signals that trigger ferroptosis ( Figure 2 )
These modifications are standard peptide chemistry strategies that preserve the core pharmacophore while improving pharmacokinetic properties
Furthermore, as estimated from the higher CLr value of S1PC (0.03 l/h/kg) compared with that of SAC (0.0086 l/h/kg), the higher systemic clearance of S1PC than SAC is probably due to its fast elimination rate
