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Two versions exist, and they behave very differently in the body

Activation of KORs (expressed in the spinal dorsal horn) can block the release of excitatory neurotransmitters, including glutamate and substance P, which in turn attenuates nociceptive signaling [62]

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Moreover, the addition of bevacizumab to chemotherapy did not lead to an improvement in OS, which was 9.4 months versus 10.9 months in placebo and bevacizumab group respectively